How do icosahedral RNA viruses package their genome?

In collaboration with the Institute of Integrative Biology of the Cell (I2BC), the Laboratoire Léon Brillouin and the European Synchrotron Radiation Facility, our team has elucidated the nonequilibrium self-assembly dynamics of an icosahedral plant virus. Starting from the purified protein subunits and the RNA genome, we have probed the spontaneous reconstitution of the virus by time-resolved small-angle X-ray scattering with a high spatiotemporal resolution. The genome acts as an assembly template by rapidly capturing the subunits, which subsequently self-organize into a protective shell. The results have been published in Nature Communications.
Contact : Guillaume Tresset