More than 292 million people are chronically infected with the Hepatitis B Virus (HBV), mainly in Africa and South Asia, due to the lack of systematic vaccination. HBV causes severe pathologies such as liver cirrhosis and hepatocellular carcinoma, sometimes leading to the death of almost a million patients …
Cryo electron microscopy (cryo-EM) has become an effective and straightforward approach to determine the structure of macromolecules in solution, trapped within a thin film (a few tens of nanometres) vitrified …
Mohamad HARASTANI has defended his PhD thesis entitled “Image analysis method development for in vitro and in situ cryo electron tomography studies of conformational variability of biomolecular complexes: case of …
DNA packaging within viruses, chromosomes or nano-devices leads to extremely compact assemblies where not only high density but also very high curvature prevail. Yet DNA is a rather stiff filament, …
RNA viruses are a family of infectious agents with sometimes dramatic health and economic consequences such as those we are currently experiencing. Over the course of a life cycle, viral …
Maelenn CHEVREUIL has defended her PhD thesis entitled Self-assembly and disassembly dynamical phenomena in icosahedral viruses under the supervision of Stéphane BRESSANELLI and Guillaume TRESSET on February 24, 2020. The …
In Eukaryotes, DNA is regularly wound into a left-handed super-helix around the histone octamer to form a chain of nucleosomes. Atomic structures have been obtained by crystallography of engineered nucleosomes. …
In collaboration with the Institute of Integrative Biology of the Cell (I2BC), the Laboratoire Léon Brillouin and the European Synchrotron Radiation Facility, our team has elucidated the nonequilibrium self-assembly dynamics …
Jacques Dubochet, Joachim Frank and Richard Henderson have been awarded the 2017 Nobel prize for Chemistry “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution” a …
On the occasion of the retirement of Françoise Livolant, the Laboratoire de Physique des Solides (LPS) and the Laboratoire de Physique Théorique et Modèles Statistiques (LPTMS) are organising an international …